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| 245 | 1 | 0 | _aInvestigations on Antimycobacterial Activity of Some Ethiopian Medicinal Plants |
| 490 | 0 | _vPhytotherapy Research, 15(4), p.323-326, 2001 | |
| 520 | 3 | _aFifteen crude extracts prepared from seven Ethiopian medicinal plants used to treat various infectious diseases were assessed for their ability to inhibit the growth of Mycobacterium tuberculosis. A preliminary screening of the crude extracts against M. tuberculosis typus humanus (ATCC 27294)was done by dilution assay using Lo¨wenstein-Jensen medium. None of the tested extracts except the acetone fraction obtained from the stem bark of Combretum molle (R. Br. ex G. Don.)Engl & Diels (Combretaceae)showed significant inhibitory action against this strain. The acetone fraction of the stem bark of C. molle caused complete inhibition at concentrations higher than 1 mg/mL. Phytochemical analysis of the bioactive fraction led to the isolation of a major tannin and two oleanane-type pentacyclic triterpene glycosides. The tannin was identified as the ellagitannin, punicalagin, whilst the saponins were characterized as arjunglucoside (also called 4-epi-sericoside)and sericoside. All the pure compounds were further tested against the ATCC strain. Punicalagin was found to inhibit totally growth of the ATCC and also of a patient strain, which was fully sensitive to the standard antituberculosis drugs, at concentrations higher than 600 g/mL and 1.2 mg/mL, respectively. On the other hand, the saponins failed to show any action on the ATCC strain. It appears that our findings are the first report of tannins exhibiting antimycobacterial activity. | |
| 700 | 1 | 2 | _aAsres, K. |
| 700 | 1 | 2 | _aBucar, F. |
| 700 | 1 | 2 | _aEdelsbrunner, S. |
| 700 | 1 | 2 | _aKartnig, T. |
| 700 | 1 | 2 | _aHöger, G. |
| 700 | 1 | 2 | _aThiel, W. |
| 856 | 4 | 0 |
_uhttps://drive.google.com/file/d/1S-zcP7XFui9bqh8E4Yo2v6Ss_Ywximo2/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
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