000			01575nam a2200241Ia 4500
003			MX-MdCICY
005			20250625124702.0
040			_cCICY
090			_aB-7515
245	1	0	_aAntioxidant action of bixin against cisplatin-induced chromosome aberrations and lipid peroxidation in rats
490	0		_vPharmacological Research, 43, p.561-566, 2001
520	3		_aCisplatin is one of the most active cytotoxic agents in the treatment of cancer, but has serious side effects, inducing nephrotoxicity and chromosome aberrations. In this study we evaluated the role of the carotenoid bixin on cisplatin-induced oxidative stress in Wistar rats through three markers of oxidative damage: chromosome aberrations, glutathione depletion and lipid peroxidation. The animals were divided into six treatment groups with six rats in each (n D6). The dose of cisplatin (5.0 mg kg..1 body wt.)was injected i.p. and bixin (2.5 or 5.0 mg kg..1 body wt.)was given by gavage at 48, 24 h and 10 min before the cisplatin injection. The treatment with the highest dose of bixin resulted in a statistically significant reduction, by about 33
650	1	4	_aBIXIN
650	1	4	_aANNATTO
650	1	4	_aLIPID PEROXIDATION
650	1	4	_aCHROMOSOME ABERRATIONS
700	1	2	_aRodrigues Silva, C.
700	1	2	_aAntunes, L.M.G.
700	1	2	_aBianchi, L.M.P.
856	4	0	_uhttps://drive.google.com/file/d/1fs81P6KbRQFtJDh2IV6H8HZUOF9x_rjR/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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