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090			_aB-7833
245	1	0	_aToxicological Effects of Alfa-Solamargine in Experimental Animals
490	0		_vPhytotherapy Research, 17(3), p.254-258, 2003
520	3		_aAlfa-Solamargine isolated from the fresh fruits of Solanum americanum Miller was studied for its toxicity. Lethality studies in rats showed a dose-mortality relationship with a LD50 of 42 mg/kg body weight intraperitoneally. The chronic and subchronic toxicity investigations indicated that the size of the glycoalkaloid dose was more important than the total glycoalkaloid intake. No appreciable toxic effects were observed at doses below 35 mg/kg body weight as indicated by blood parameters, enzyme levels and histological sections of kidney, liver and cardiac muscle. á-Solamargine did not affect the weight of the testes and epididymis or the number of spermatozoa but produced a slight irritation and congestion in the epididymis and testis at doses up to 50 mg/kg body weight.
650	1	4	_aSOLAMARGINE
650	1	4	_aSOLANACEAE
650	1	4	_aGLYCOALKALOIDS
650	1	4	_aTOXICOLOGY
650	1	4	_aPHARMACOLOGY
700	1	2	_aChami, L.A.
700	1	2	_aMéndez, B
700	1	2	_aChataing, B.
700	1	2	_aO'Callaghan, J.
700	1	2	_aUsubillaga, A
700	1	2	_aLaCruz, L.
856	4	0	_uhttps://drive.google.com/file/d/1Vb2yxmzRfhqiaPi5h7XxHEdgZPLJl9xG/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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