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090			_aB-7900
245	1	0	_aSynthesis and biological evaluation of 4-imidazolylflavans as nonsteroidal aromatase inhibitors
490	0		_vBioorganic Chemistry, 32(6), p.494-503, 2004
520	3		_aA series of 4-imidazolylflavans having a variety of substituents on the 2-phenyl ring was synthesized and investigated for their inhibitory effect against aromatase. Structure-activity relationships of these compounds were determined. An additional chlorine atom or a cyano group at the 40 position did not enhance aromatase inhibition as well as a 30-hydroxyl group. The influence of an additional 40-hydroxyl group depends on the substitution pattern of A ring. Among these molecules, 40-hydroxy-4-imidazolyl-7-methoxyflavan is only 2.2-fold less active than the letrozole (as assessed by IC50 values). Letrozole is used as the first-line therapy for metastatic breast cancer.
650	1	4	_a4-IMIDAZOLYLFLAVANS
650	1	4	_aBREAST CANCER
650	1	4	_aANTI-AROMATASE EFFECT
650	1	4	_aSTRUCTURE-ACTIVITY RELATIONSHIPS
700	1	2	_aPouget, C.
700	1	2	_aYahiaoui,S.
700	1	2	_aFagnere, C.
700	1	2	_aHabrioux, G.
700	1	2	_aChulia, A.J.
856	4	0	_uhttps://drive.google.com/file/d/1v6LIwEaRFYSWdICcvmjpPESfy6FTSW97/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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