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245	1	0	_aEarly Steps in the Biosynthesis of NAD in Arabidopsis Start with Aspartate and Occur in the Plastid1
490	0		_vPlant Physiology, 141, p.851-857, 2006
520	3		_aNADis a ubiquitous coenzyme involved in oxidation-reduction reactions and is synthesized by way of quinolinate. Animals and some bacteria synthesize quinolinate from tryptophan, whereas other bacteria synthesize quinolinate from aspartate (Asp)using L-Asp oxidase and quinolinate synthase. We show here that Arabidopsis (Arabidopsis thaliana)uses the Asp-to-quinolinate pathway. The Arabidopsis L-Asp oxidase or quinolinate synthase gene complemented the Escherichia coli mutant defective in the corresponding gene, and T-DNA-based disruption of either of these genes, as well as of the gene coding for the enzyme quinolinate phosphoribosyltransferase, was embryo lethal. An analysis of functional green fluorescent protein-fused constructs and in vitro assays of uptake into isolated chloroplasts demonstrated that these three enzymes are located in the plastid.
700	1	2	_aKatoh, A.
700	1	2	_aUenohara, K.
700	1	2	_aAkita, M.
700	1	2	_aHashimoto, T.
856	4	0	_uhttps://drive.google.com/file/d/1ZRFcb4kviNXuBeIM79Juo4VhZbKUyc96/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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