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090			_aB-7967
245	1	0	_aS tudies on the metabolism and toxicological detection of the Eschscholtzia californica alkaloids californine and protopine in urine using gas chromatography-mass spectrometry
490	0		_vJournal of Chromatography B, 789(1), p.43-47, 2003
520	3		_aEschscholtzia californica preparations are in use as phytopharmaceuticals and as herbal drugs. Studies are described on the metabolism and the toxicological analysis of the Eschscholtzia californica alkaloids californine and protopine in rat urine using gas chromatography-mass pectrometry. The identified metabolites indicated that californine is extensively metabolized by N-demethylation and/or single or double demethylenation with consecutive catechol-O-methylation of one of the hydroxy groups. Protopine, however, only undergoes extensive demethylenation of the 2,3-methylenedioxy group followed by catechol-O-methylation. All phenolic hydroxy metabolites were found to be partly conjugated. The authors' systematic toxicological analysis procedure using full-scan gas chromatography-mass spectrometry after acid hydrolysis, liquid-liquid extraction and microwave-assisted acetylation allowed the detection of the main metabolites of californine and protopine in rat urine after a dose which should correspond to that of drug users. Therefore, use of Eschscholtzia californica preparations should also be detectable in human urine by the authors' systematic toxicological analysis procedure.
650	1	4	_aESCHSCHOLTZIA CALIFORNICA
650	1	4	_aALKALOIDS
650	1	4	_aCALIFORNINE
650	1	4	_aPROTOPINE
700	1	2	_aLiane D. Paul
700	1	2	_aMaurer, H.H.
856	4	0	_uhttps://drive.google.com/file/d/18Oxgd8RfsRUd5uVmMd6fs1GuoGyYU9Li/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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