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090 _aB-8182
245 1 0 _aFunctional genome of the human pathogenic fungus Paracoccidioides brasiliensis
490 0 _vFEMS Immunology and Medical MicroBiology, 45(3), p.369-381, 2005
520 3 _aParacoccidioides brasiliensis is a dimorphic and thermo-regulated fungus which is the causative agent of paracoccidioidomycosis, an endemic disease widespread in Latin America. Pathogenicity is assumed to be a consequence of the cellular differentiation process that this fungus undergoes from mycelium to yeast cells during human infection. In an effort to elucidate the molecular mechanisms involved in this process a network of Brazilian laboratories carried out a transcriptome project for both cell types. This review focuses on the data analysis yielding a comprehensive view of the fungal metabolism and the molecular adaptations during dimorphism in P. brasiliensis from analysis of 6022 groups, related to expressed genes, which were generated from both mycelium and yeast phase
650 1 4 _aTRANSCRIPTOME
650 1 4 _aFUNCTIONAL GENOMICS
650 1 4 _aMETABOLISM
650 1 4 _aCELL DIFFERENTIATION
650 1 4 _aHOST-PATHOGEN INTERACTION
650 1 4 _aPARACOCCIDIOIDES BRASILIENSIS
700 1 2 _aFelipe, M.S.S.
700 1 2 _aTorres, F.A.G.
700 1 2 _aMaranhao, A.Q.
856 4 0 _uhttps://drive.google.com/file/d/1qGsheco1ZHS4ddo1sjxuai3-eqB6lme9/view?usp=drivesdk
_zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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