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090			_aB-8548
245	1	0	_aInteractions of PIN and PGP auxin transport mechanisms
490	0		_vBiochem. Soc. Trans. , 35(1), p.137-141, 2007
520	3		_aPolarized transport of the plant hormone auxin influences multiple growth processes in plants and is regulated by plasma-membrane-localized efflux and uptake carriers. The PGP (P-glycoprotein)ABC transporters (ATP-binding-cassette transporters), PIN (pin-formed)subfamily of major facilitator proteins and members of AUX/LAX families have been shown to independently transport auxin both in planta and in heterologous systems. However, PIN- and PGP-mediated transport in heterologous systems exhibits decreased substrate specificity and inhibitor-sensitivity compared with what is seen in plants and plant cells. To determine whether PIN-PGP interactions enhance transport specificity, we analysed interactions of the representative auxin-transporting PGPs with PIN1 and AUX1 in planta and in heterologous systems. Here, we provide evidence that PINs and PGPs interact and function both independently and co-ordinately to control polar auxin transport and impart transport specificity and directionality. These interactions take place in protein complexes stabilized by PGPs in detergent-resistant microdomains.
700	1	2	_aBandyopadhyay, A.
700	1	2	_aBlakeslee, J.J.
700	1	2	_aLee, O.R.
700	1	2	_aMravec, J.
700	1	2	_aSauer, M.
700	1	2	_aTitapiwatanakun, B.
700	1	2	_aMakam, S.N.
700	1	2	_aMakam, S.N.
700	1	2	_aGeisler, M.
700	1	2	_aMartinoia, E.
700	1	2	_aFriml, J.
700	1	2	_aPeer, W.A.
700	1	2	_aMurphy, A.S.
856	4	0	_uhttps://drive.google.com/file/d/1U-Pu22ngtBVr9MCXN4i9TSrGNY7rWCrH/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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