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245	1	0	_aProduction of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation
490	0		_vNature Immunology, 8, p.514-521, 2007
520	3		_aAntigen receptor-mediated production of inositol-1,4,5-trisphosphate (Ins(1,4,5)P3)in lymphocytes triggers the release of Ca2+ from intracellular stores; this release of Ca2+ results in the opening of store-operated Ca2+ channels in the plasma membrane. Here we report that mice lacking Ins(1,4,5)P3 3-kinase B (Itpkb), which converts Ins(1,4,5)P3 to inositol-1,3,4,5- tetrakisphosphate (Ins(1,3,4,5)P4), had impaired B lymphocyte development and defective immunoglobulin G3 antibody responses to a T lymphocyte-independent antigen. Itpkb-deficient B lymphocytes had the phenotypic and functional features of tolerant B lymphocytes and showed enhanced activity of store-operated Ca2+ channels after B lymphocyte receptor stimulation which was reversed by the provision of exogenous Ins(1,3,4,5)P4. Our data identify Itpkb and its product Ins(1,3,4,5)P4 as inhibitors of store-operated Ca2+ channels and crucial regulators of B cell selection and activation.
700	1	2	_aMiller, A.T.
700	1	2	_aSandberg, M.
700	1	2	_aHuang, Y.H.
700	1	2	_aYoung, M.
700	1	2	_aSutton, S.
700	1	2	_aSauer, K.
700	1	2	_aCooke, M.P.
856	4	0	_uhttps://drive.google.com/file/d/1AYqjXQ4yE-DLzvr_jDAlztsG89TPfrTn/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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