000			02147nam a2200301Ia 4500
003			MX-MdCICY
005			20250625124729.0
040			_cCICY
090			_aB-8935
245	1	0	_aMgMfs1, a major facilitator superfamily transporter from the fungal wheat pathogen Mycosphaerella graminicola, is a strong protectant against natural toxic compounds and fungicides
490	0		_vFungal Genetics and Biology, 44(5), p.378-388, 2007
520	3		_aMgMfs1, a major facilitator superfamily (MFS)gene from the wheat pathogenic fungus Mycosphaerella graminicola, was identiWed in expressed sequence tag (EST)libraries. The encoded protein has high homology to members of the drug:H+ antiporter eZux family of MFS transporters with 14 predicted transmembrane spanners (DHA14), implicated in mycotoxin secretion and multidrug resistance. Heterologous expression of MgMfs1 in a hypersensitive Saccharomyces cerevisiae strain resulted in a strong decrease in sensitivity of this organism to a broad range of unrelated synthetic and natural toxic compounds. The sensitivity of MgMfs1 disruption mutants of M. graminicola to most of these compounds was similar when compared to the wild-type but the sensitivity to strobilurin fungicides and the mycotoxin cercosporin was increased. Virulence of the disruption mutants on wheat seedlings was not aVected. The results indicate that MgMfs1 is a true multidrug transporter that can function as a determinant of pathogen sensitivity and resistance to fungal toxins and fungicides.
650	1	4	_aMFS TRANSPORTER
650	1	4	_aMYCOSPHAERELLA GRAMINICOLA
650	1	4	_aMULTIDRUG RESISTANCE
650	1	4	_aFUNGICIDE
650	1	4	_aSTROBILURIN
650	1	4	_aCERCOSPORIN
650	1	4	_aSEPTORIA TRITICI LEAF BLOTCH
650	1	4	_aSACCHAROMYCES CEREVISIAE
700	1	2	_aRoohparvar, R.
700	1	2	_aDe Waard, M.A.
700	1	2	_aKema, G.H.J.
700	1	2	_aZwiers, L.H.
856	4	0	_uhttps://drive.google.com/file/d/1STDllH8GN6iaDoWkQ3azAOjsxgnPTEmK/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942			_2Loc _cREF1
008			250602s9999 xx |||||s2 |||| ||und|d
999			_c43197 _d43197