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245	1	0	_aThe antileishmanial activity assessment of unusual flavonoids from Kalanchoe pinnata
490	0		_vPhytoChemistry, 67(18), p.2071-2077, 2006
520	3		_aThe importance of flavonoids for the antileishmanial activity of Kalanchoe pinnata was previously demonstrated by the isolation of quercitrin, a potent antileishmanial flavonoid. In the present study, the aqueous leaf extract from the medicinal plant K. pinnata (Crassulaceae)afforded a kaempferol di-glycoside, named kapinnatoside, identified as kaempferol 3-O-a-L-arabinopyranosyl (1! 2)a-Lrhamnopyranoside (1). In addition, two unusual flavonol and flavone glycosides already reported, quercetin 3-O-a-L-arabinopyranosyl (1! 2)a-L-rhamnopyranoside (2)and 40,5-dihydroxy-30,8-dimethoxyflavone 7-O-b-D-glucopyranoside (3), have been isolated. Their structures were determined via analyses of mono and bi-dimensional 1H and 13C NMR spectroscopic experiments and HR-MALDI mass spectra. Because of its restricted occurrence and its abundance in K. pinnata, flavonoid (2)may be a chemical marker for this plant species of high therapeutic potential. The three flavonoids were tested separately against Leishmania amazonenis amastigotes in comparison with quercitrin, quercetin and afzelin. The quercetin aglycone - type structure, as well as a rhamnosyl unit linked at C-3, seem to be important for antileishmanial activity.
650	1	4	_aKALANCHOE PINNATA
650	1	4	_aCRASSULACEAE
650	1	4	_aLEISHMANIASIS
650	1	4	_aNMR
650	1	4	_aFLAVONOIDS
650	1	4	_aKAEMPFEROL 3-O-A-L-ARABINOPYRANOSYL (1!2)A-L-RHAMNOPYRANOSIDE
700	1	2	_aMuzitano, M.F.
700	1	2	_aTinoco, L.W.
700	1	2	_aGuette, C.
700	1	2	_aKaiser, C.R.
700	1	2	_aRossi-Bergmann, B.
856	4	0	_uhttps://drive.google.com/file/d/1-FXRN0T6k71yGnavdvi9Wakx-Qd_h4XD/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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