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245 1 0 _aEfficient synthesis of small molecule macroarrays: optimization of the macroarray synthesis platform and examination of microwave and conventional heating methods
490 0 _vTetrahedron, 62(19), p.4715-4727, 2006
520 3 _aWe report a method for the efficient construction of small molecule macroarrays using microwave-assisted SPOT-synthesis. Macroarrays of 1,3-diphenylpropenones (chalcones)were synthesized rapidly and in high purity starting from robust,Wang-linker-derivatized planar supports.We have optimized the entire chalcone macroarray construction process and evaluated the efficiency and utility of microwave-assisted reactions in array synthesis. Microwave heating was found to be most beneficial for reactions that require temperatures greater than the boiling points of the solvents. These microwave-assisted conditions permitted straightforward access to macroarrays of 2,4,6-triarylpyridines derived from the original chalcone scaffold.
700 1 2 _aBowman, M. D.
700 1 2 _aJacobson, M. M.
700 1 2 _aPujanauski, B. J.
700 1 2 _aBlackwell, H. E.
856 4 0 _uhttps://drive.google.com/file/d/1iFexGsctdmK02Ryc5Qku9iBp5raZ5C8l/view?usp=drivesdk
_zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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