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| 005 | 20250625124733.0 | ||
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| 090 | _aB-9142 | ||
| 245 | 1 | 0 | _aPrenylation enhances cytotoxicity of apigenin and liquiritigenin in rat H4IIE hepatoma and C6 glioma cells |
| 490 | 0 | _vFood and Chemical Toxicology, 45(1), p.119-124, 2006 | |
| 520 | 3 | _aAntioxidative as well as cytotoxic effects of the prenylated flavonoids licoflavone C (8-prenylapigenin)and isobavachin (8-prenylliquiritigenin)were investigated in comparison to the corresponding non-prenylated flavonoids (apigenin, liquiritigenin)and vitexin (apigenin-C8-glucoside)using metabolically active H4IIE hepatoma and metabolically poorly active C6 glioma cells. None of the substances showed radical scavenging activities in the 2,2-diphenyl-1-picrylhydrazyl (DPPH)-assay nor were they effective in protection against H2O2-induced intracellular 20,70-dichlorodihydrofluorescein (H2DCF)oxidation (fluorescent probe for oxidative stress)in H4IIE and C6 cells. When the intrinsic effects of the substances were investigated, licoflavone C and isobavachin exerted a pronounced toxicity in both H4IIE (IC50 values of 42 ± 5 and 96 ± 19 lmol/L)and C6 cells (IC50 values of 37 ± 6 and 69 ± 3 lmol/L)while the non-prenylated analogues as well as the glycosylated derivate vitexin showed almost no cytotoxic effect up to 250 lmol/L. In H4IIE cells the induction of apoptotic cell death by licoflavone C and icobavachin was detected as an activation of caspase 3/7 (6- and 3.3-fold, respectively). Based on these experiments we suggest that C8-prenylation of a flavonoid enhances the cytotoxicity inducing an apoptotic cell death in H4IIE cells without affecting antioxidative properties. | |
| 650 | 1 | 4 | _aAPOPTOSIS |
| 650 | 1 | 4 | _aCYTOTOXICITY |
| 650 | 1 | 4 | _aDPPH ASSAY |
| 650 | 1 | 4 | _aOXIDATIVE STRESS |
| 700 | 1 | 2 | _aWatjen, W. |
| 700 | 1 | 2 | _aWeber, W. |
| 700 | 1 | 2 | _aLou, YJ. |
| 700 | 1 | 2 | _aWang, ZQ. |
| 700 | 1 | 2 | _aChovolou, Y. |
| 700 | 1 | 2 | _aKampkotter, A. |
| 700 | 1 | 2 | _aProksch, P. |
| 856 | 4 | 0 |
_uhttps://drive.google.com/file/d/1ClvBmkLpxqOstTKHFjYcyZNTGHSQevyq/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
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