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245	1	0	_aSynthesis of prenylated benzaldehydes and their use in the synthesis of analogues of licochalconeA
490	0		_vEuropean Journal of Medicinal Chemistry, 39(11), 2004
520	3		_aIn this paper, a general applicable synthesis of prenylated aromatic compounds exemplified by prenylated benzaldehydes starting from readily available acetophenones is described. The synthesized benzaldehydes are used to prepare a number of novel analogues of Licochalcone A, a known antibacterial compound, and for the exploration of the pharmacophoric elements that are essential for the antibacterial activity. It is shown that the hydroxyl group in the A ring is essential for the activity and that the hydroxyl group in the B ring has no influence on the antibacterial effect of Licochalcone A. Furthermore, it is shown that the prenyl group at the position 5 f the B ring also has a dominating influence on the activity. This aliphatic group can be replaced by other lipophilic long chained substituents in order to maintain the activity.
700	1	2	_aKromann, H.
700	1	2	_aLarsen, M.
700	1	2	_aBoesen, T.
700	1	2	_aSchønning, K.
700	1	2	_aNielsen, S.F.
856	4	0	_uhttps://drive.google.com/file/d/1rYcBZ0aWL7DjHRkMzOxu7UJy02Q2EOFv/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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