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245 1 0 _aIn vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens
490 0 _vBioorganic & Medicinal Chemistry Letters, 18(4), p.1511-1514, 2008
520 3 _aFour flavones, 3,40-O-dimethylquercetin (1), 3,7-O-dimethylquercetin (2), 3-O-methylquercetin (3)and 3,7,40-O-trimethylquercetin (4)were isolated as the inhibitors of nitric oxide production in activated microglia (IC50 values: 11.1, 4.2, 3.8, and 25.1 lM, respectively). They suppressed the expression of protein and mRNA of inducible nitric oxide synthase. Furthermore, compounds 2 and 3 showed scavenging activity of peroxynitrite with SC50 values of 1.75 and 0.77 lM, respectively.
700 1 2 _aKim, J.Y.
700 1 2 _aLim, H.J.
700 1 2 _aRyu, J.H.
856 4 0 _uhttps://drive.google.com/file/d/1F1ZtMxDXWMmBJBOSbYclL60fTGvw26BS/view?usp=drivesdk
_zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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