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245	1	0	_aStructural aspects of antioxidant activity of flavonoids
490	0		_vFree Radical Biology & Medicine, 20(3), p.331-342, 1996
520	3		_aFlavonoids, a group of naturally occurring antioxidants and iron chelators, might be used as cardioprotective agents in doxorubicin-induced cardiotoxicity, which is believed to be caused by the formation of oxygen free radicals. To investigate the underlying molecular mechanism, we tested a large group of flavonoids from all major structural subclasses on their ability to inhibit doxorubicin (enzymatically)-induced and e2+/ascorbate (nonenzymatically)-induced microsomal lipid peroxidation (LPO)and to chelate Fe 2÷ . In addition, we measured half peak oxidation potentials (Ep/2). LPO inhibition data gave a good qualitative correlation with the oxidation potentials. Most flavonoids tested chelated Fe 2÷, but there were large differences in the chelating capacity. For good scavenging activity, a catechol moiety on ring B is required. The 3-OH moiety can function as a chelation site and can also be oxidized. The 3-OH group in combination with a C2 C3 double bond, increases the cavenging activity. Fe 2÷ chelation only plays a role in the LPO inhibition by less active scavengers. Chelation can then raise the activity to the level of the most active scavengers, possibly by site-specific scavenging. It can be concluded that Ep/2 values and iron chelating activity can almost completely describe the LPO inhibiting behaviour of the flavonoids.
650	1	4	_aFREE RADICALS
650	1	4	_aANTIOXIDANT
650	1	4	_aFLAVONOID
650	1	4	_aOXIDATION POTENTIAL
650	1	4	_aLIPID PEROXIDATION
700	1	2	_aVan Acker, S.A.B.E.
700	1	2	_aVan Den Berg, D.J.
700	1	2	_aTromp, M.J.L.
700	1	2	_aGriffioen, D.H.
700	1	2	_aVan Bennekom, W.P.
700	1	2	_aVan Der Vijgh, W.J.F.
700	1	2	_aBast, A.
856	4	0	_uhttps://drive.google.com/file/d/1_tdzNoeHTxkRpp7MTVBQwa1LvhvEZTLN/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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