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245	1	0	_aIsoquercitrin from Argemone platyceras inhibits carbachol and leukotriene D4-induced contraction in guinea-pig airways
490	0		_vEuropean Journal of Pharmacology, 522(1-3), p.108-115, 2005
520	3		_aArgemone platyceras is used in Mexico as a remedy for cough, bronchitis and pneumonia. The present study was performed to investigate the pharmacological anti-asthmatic properties of Argemone platyceras on airways and to identify its active principles. Methanol extracts of leaves and flowers, subsequent organic and aqueous extraction phases, and silica gel chromatography fractions were assayed on the carbachol-induced response, and/or on ovalbumin antigenic challenge, and on leukotriene D4-induced response of tracheae from sensitized and non-sensitized guinea-pigs. Methanol extracts, ethyl-acetate phase, and its fractions 6 and 7 inhibited the carbachol-induced contractile esponse. Isoquercitrin and rutin were the main compounds found in fractions 6 and 7 respectively. Isoquercitrin (fraction 6)abolished the response to ovalbumin, and decreased the contractile response to leukotriene D4. Because of its effect on carbachol-induced contractile response, on the late-phase response to ovalbumin, and on leukotriene D4-induced contractile response, isoquercitrin might be highly useful in treatment of asthma
650	1	4	_aISOQUERCITRIN
650	1	4	_aRUTIN
650	1	4	_aASTHMA
650	1	4	_aCARBACHOL
650	1	4	_aARGEMONE PLATYCERAS
650	1	4	_aANTIGEN CHALLENGE
650	1	4	_aANTI-ASMATHIC PROPERTIES
650	1	4	_aANTI-LEUKOTRIENE ACTION
700	1	2	_aFernandez, J.
700	1	2	_aReyes, R.
700	1	2	_aPonce, H.
700	1	2	_aOropeza, M.
700	1	2	_aVancalsteren, M.R.
700	1	2	_aJankowski, C.
700	1	2	_aCampos, M.G.
856	4	0	_uhttps://drive.google.com/file/d/1V7VieSqBP5jF6dyqNoQ_S-MpewSDHbMY/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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