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090			_aB-9651
245	1	0	_aThe Molecular Biology of Secreted Enzyme Production by Fungi
490	0		_vCritical Reviews in Biotechnology, 17(4), p.273-306, 1997
520	3		_aEnzymes from filamentous fungi are already widely exploited, but new applications for known enzymes and new enzymic activities continue to be found. In addition, enzymes from less amenable non-fungal sources require heterologous production and fungi are being used as the production hosts. In each case there is a need to improve production and to ensure quality of product. While conventional, mutagenesis-based, strain improvement methods will continue to be applied to enzyme production from filamentous fungi the application of recombinant DNA techniques is beginning to reveal important information on the molecular basis of fungal enzyme production and this knowledge is now being applied both in the laboratory and commercially. We review the current state of knowledge on the molecular basis of enzyme production by filamentous fungi. We focus on transcriptional and post-transcriptional regulation of protein production, the transit of proteins through the secretory pathway and the structure of the proteins produced including glycosylation.
650	1	4	_aFUNGUS
650	1	4	_aENZYME
650	1	4	_aPROTEIN SECRETION
650	1	4	_aGLYCOSYLATION
650	1	4	_aASPERGILLUS
650	1	4	_aTRICHODERMA
650	1	4	_aHETEROLOGOUS GENE EXPRESSION
700	1	2	_aArcher, D.B.
700	1	2	_aPeberdy, J.E.
856	4	0	_uhttps://drive.google.com/file/d/1US8Q_kOMWg5lgW8EZm96rhyU-zAfHk1l/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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