000			01785nam a2200289Ia 4500
003			MX-MdCICY
005			20250625140617.0
040			_cCICY
090			_aB-9667
245	1	0	_aSynthesis of Plumbagin Derivatives and their Inhibitory Activities against Ehrlich Ascites Carcinoma in vivo and Leishmania donovani Promastigotes in vitro
490	0		_vPhytotherapy Research, 16(2), p.133-137, 2002
520	3		_aPlumbagin, a plant-derived bioactive naphthoquinonoid compound, was converted to a hydroquinonoid derivative, which was studied for its tumour-inhibitory and antileishmanial activities for the first time. A similar chemical transformation was undertaken on an analogous dimeric compound, diospyrin, and its bioassay results were compared with those of the plumbagin derivative. Synthesis of the derivative of plumbagin did not result in a marked enhancement of the tumour-inhibitory activity, whereas the improvement was obvious in the case of diospyrin vis a` vis its hydroquinonoid analogue. The conversion of diospyrin to the hydroquinonoid compound also led to a substantial increase in the antileishmanial activity, while a similar conversion of plumbagin failed to do so.
650	1	4	_aPLUMBAGIN DERIVATIVE
650	1	4	_aDIOSPYRIN DERIVATIVE
650	1	4	_aNAPHTHOQUINONE DERIVATIVE
650	1	4	_aEHRLICH ASCITES CARCINOMA
650	1	4	_aLEISHMANIA DONOVANI
700	1	2	_aHazra, B.
700	1	2	_aSarkar, R.
700	1	2	_aBhattacharyya, S.
700	1	2	_aGhosh, P.K.
700	1	2	_aChel, G.
700	1	2	_aDinda, B.
856	4	0	_uhttps://drive.google.com/file/d/1XWZK2fwTpihtp12f-7luGWwqDAODguGD/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942			_2Loc _cREF1
008			250602s9999 xx |||||s2 |||| ||und|d
999			_c43913 _d43913