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| 090 | _aB-9993 | ||
| 245 | 1 | 0 | _aEffects of aluminium exposure on brain glutamate and GABA systems: an experimental study in rats |
| 490 | 0 | _vFood and Chemical Toxicology, 39(12), p.1285-1289, 2001 | |
| 520 | 3 | _aIt has been postulated that the neurotoxic effects of aluminium could be mediated through glutamate,an excitatory amino acid. Hence the effects of aluminium administration (at a dose of 4.2 mg/kg body weight daily as aluminium chloride,hexahydrate, intraperitoneally,for 4 weeks)on glutamate and g-amino butyrate (GABA),an inhibitory amino acid, and related enzyme activities in different regions of the brain were studied in albino rats. The glutamate level increased significantly in the cerebrum,thalamic area,midbrain-hippocampal region and cerebellum in response to in vivo aluminium exposure. The aluminium insult also caused significant increases in glutamate a-decarboxylase activity in all the brain regions. However,on aluminium insult,the GABA content was not significantly changed except in the thalamic area,where it was elevated. On the contrary,the GABA-T activities of all the regions were reduced significantly in all regions except the midbrain-hippocampal region. However,the succinic semi-aldehyde content of all brain regions increased,often significantly. The aluminium-induced modification of the enzyme activities may be either due to the direct impact of aluminium or due to aluminium-induced changes in the cellular environment. The aluminiuminduced differential regional accumulation of glutamate or other alterations in enzymes of the glutamate-GABA system may be one of the causes of aluminium-induced neurotoxicity | |
| 650 | 1 | 4 | _aALUMINIUM |
| 650 | 1 | 4 | _aBRAIN |
| 650 | 1 | 4 | _aGLUTAMATE |
| 650 | 1 | 4 | _aGAD |
| 650 | 1 | 4 | _aGABA |
| 650 | 1 | 4 | _aGABA-T |
| 650 | 1 | 4 | _aSSA |
| 700 | 1 | 2 | _aNayak, P. |
| 700 | 1 | 2 | _aChatterjee, A.K. |
| 856 | 4 | 0 |
_uhttps://drive.google.com/file/d/1z_pSK3ko6BPX8PoO4hGVq9XN0h7NTKYV/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
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