000			01715nam a2200229Ia 4500
003			MX-MdCICY
005			20250625140630.0
040			_cCICY
090			_aB-10369
245	1	0	_aHundreds of Ankyrin-Like Repeats in Functionally Diverse Proteins: Mobile Modules That Cross Phyla Horizontally?
490	0		_vPROTEINS: Structure, Function, and Genetics, 17(4), p.363-174, 1993
520	3		_aBased on pattern searches and systematic database screening, almost 650 different ankyrin-like (ANK)repeats from nearly all phyla have been identified; more than 150 of them are reported here for the first time. Their presence in functionally diverse proteins such as enzymes, toxins, and transcription factors strongly suggests domain shuffling, but their occurrence in prokaryotes and yeast excludes exon shuffling. The spreading mechanism remains unknown, but in at least three cases horizontal gene transfer appears to be involved. ANK repeats occur in at least four consecutive copies. The terminal repeats are more variable in sequence. One feature of the internal repeats is a predicted central hydrophobic a-helix, which is likely to interact with other repeats. The functions of the ankyrin-like repeats are compatible with a role in protein-protein interactions.
650	1	4	_aSEQUENCE ANALYSIS
650	1	4	_aHOMOLOGY ANK REPEAT
650	1	4	_aHORIZONTAL GENE TRANSFER
650	1	4	_aCELL CYCLE PROTEINS
650	1	4	_aTRANSCRIPTION FACTOR NF-KB
700	1	2	_aBork, P.
856	4	0	_uhttps://drive.google.com/file/d/1nEb3WxYJOjhsY1MSQ7gAlCcTV5xlSlzg/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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999			_c44607 _d44607