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245	1	0	_aGRKs and b-arrestins: roles in receptor silencing, trafficking and signaling
490	0		_vTrends in Endocrinology & Metabolism, 17(4), p.159-165, 2006
520	3		_aStimulation of cell-surface seven-transmembrane receptors (7TMRs)elicits biological responses to a wide range of extracellular signals, including many hormones. Classically, heterotrimeric GTP-binding proteins (G proteins)are recruited to the activated conformation of 7TMRs. Only two other families of protein have this remarkable characteristic: G-proteincoupled receptor kinases and b-arrestins. These two protein families have long been known to have a central and coordinated role in the 'desensitization' of G protein activation by 7TMRs. In addition, G-protein-coupled receptor kinases and b-arrestins are involved in an increasing number of interactions with non-receptor proteins, broadening the variety of their cellular functions. These newly appreciated attributes of these two families of protein highlight their unique ability to coordinate the various aspects of 7TMR functions.
700	1	2	_aReiter, E.
700	1	2	_aLefkowitz, R.J.
856	4	0	_uhttps://drive.google.com/file/d/1IN65Hd8gHdYZ9aNuGhhdMXIpzVAvguQd/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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