000			01297nam a2200181Ia 4500
003			MX-MdCICY
005			20250625140636.0
040			_cCICY
090			_aB-10701
245	1	0	_aArresting developments in heptahelical receptor signaling and regulation
490	0		_vTrends in Cell Biology, 12, p.130-138, 2002
520	3		_aIt is well established that the function of most heptahelical receptors (seven-transmembrane-span receptors; 7TMRs)is tightly regulated by the desensitizing actions of arrestins. Desensitization is the waning of 7TMR-mediated signals after prolonged exposure to agonist and occurs when arrestins bind to agonist-occupied and phosphorylated receptors, uncoupling the receptors from G proteins and preventing further signaling. Recently, there has been a marked shift in the focus of research into arrestin function because it has become clear that they not only prevent signaling from 7TMRs but also initiate and direct new signals from the very 7TMRs that they desensitize.
700	1	2	_aPerry, S.J.
700	1	2	_aLefkowitz, R.L.
856	4	0	_uhttps://drive.google.com/file/d/1QHiux04PuzCe-5ha0EKbiIt5-pOYK9nh/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942			_2Loc _cREF1
008			250602s9999 xx |||||s2 |||| ||und|d
999			_c44933 _d44933