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090			_aB-10716
245	1	0	_aAntiviral effect of octyl gallate against DNA and RNA viruses
490	0		_vAntiviral Research, 73(2), p.85-91, 2007
520	3		_aThe effects of gallic acid (3,4,5-trihydroxybenzoic acid)and its alkyl esters on virus growth and virion infectivity were examined. All the compounds tested showed an inhibitory effect on the growth of herpes simplex virus type 1 (HSV-1)in HEp-2 or Vero cells. The antiviral activity of gallic acid alkyl esters was enhanced by increasing the number of carbon in the alkyl moieties of the compounds, reaching maximum at a carbon number of 12 (lauryl gallate), but both cytocidal activity and cytopathic effect of the compounds were also significantly increased simultaneously. Among these compounds, octyl gallate showed a marked antiviral effect with a relatively moderate cytotoxity. In addition, octyl gallate suppressed the multiplication of RNA viruses, such as vesicular stomatitis virus and poliovirus. Quantitative characterization of the HSV-1 infection in the presence of octyl gallate revealed that: (1)this reagent can directly inactivate HSV-1 (virucidal activity), (2)it suppresses both the ntracellar multiplication and the release of the virus, (3)it selectively accelerates death of the virus-infected cells and (4)the addition of the reagent even at 6-h post infection completely abolishes the formation of progeny virus in the infected cells.
650	1	4	_aOCTYL GALLATE
650	1	4	_aGALLIC ACID
650	1	4	_aCELL DEATH
650	1	4	_aHERPES SIMPLEX VIRUS
650	1	4	_aPOLIOVIRUS
700	1	2	_aUozaki, M.
700	1	2	_aYamasaki, H.
700	1	2	_aKatsuyama, Y.
700	1	2	_aHiguchi, M.
700	1	2	_aHiguti, T.
700	1	2	_aKoyama, H.
856	4	0	_uhttps://drive.google.com/file/d/1YLbMamWrIxkRx-vbHoq0d_A1GJEJJwui/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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