000			01850nam a2200217Ia 4500
003			MX-MdCICY
005			20250625140637.0
040			_cCICY
090			_aB-10721
245	1	0	_aG Protein-Coupled Receptor Connectivity to NF-B in Inflammation and Cancer
490	0		_vInternational Reviews of Immunology, 27(5), p.320-350, 2008
520	3		_aComplex intracellular network interactions regulate gene expression and cellular behavior. Whether at the site of inflammation or within a tumor, individual cells are exposed to a plethora of signals. The transcription factor nuclear factor-kappaB (NF-êB)regulates genes that control key cellular activities involved in inflammatory diseases and cancer. NF-êB is regulated by several distinct signaling pathways that may be activated individually or simultaneously. Multiple ligands and heterologous cell-cell interactions have an impact on NF-êB activity. The G protein-coupled receptor (GPCR)superfamily makes up the largest class of transmembrane receptors in the human genome and has multiple molecularly distinct natural ligands. GPCRs regulate proliferation, differentiation, and chemotaxis and play a major role in inflammatory diseases and cancer. Both GPCRs and NF-êB have been, and continue to be, major targets for drug discovery. A clear understanding of network interactions between GPCR signaling pathways and those that control NF-kB may be valuable for the development of better drugs and drug combinations.
650	1	4	_aINFLAMMATION
650	1	4	_aCANCER
650	1	4	_aGPCR
650	1	4	_aNUCLEAR FACTOR-KAPPA B
700	1	2	_aFraser, C.C.
856	4	0	_uhttps://drive.google.com/file/d/1i-XSRoMRvTMWzkh5Bc59fHNIr7gn6eOv/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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