000			01444nam a2200181Ia 4500
003			MX-MdCICY
005			20250625140637.0
040			_cCICY
090			_aB-10751
245	1	0	_aUbiquitin ligases: cell-cycle control and cancer
490	0		_vNature Reviews Cancer, 6(5), p.369-381, 2006
520	3		_aA driving force of the cell cycle is the activation of cyclin-dependent kinases (CDKs), the activities of which are controlled by the ubiquitin-mediated proteolysis of key regulators such as cyclins and CDK inhibitors. Two ubiquitin ligases, the SKP1-CUL1-F-boxprotein (SCF)complex and the anaphase-promoting complex/cyclosome (APC/C), are responsible for the specific ubiquitylation of many of these regulators. Deregulation of the proteolytic system might result in uncontrolled proliferation, genomic instability and cancer. Cumulative clinical evidence shows alterations in the ubiquitylation of cell-cycle regulators in the aetiology of many human malignancies. A better understanding of the ubiquitylation machinery will provide new insights into the regulatory biology of cell-cycle transitions and the development of anti-cancer drugs.
700	1	2	_aNakayama, K.I.
700	1	2	_aNakayama, K.
856	4	0	_uhttps://drive.google.com/file/d/1Mb4-4MQbFl5s1MK3FPdXtUS1Sz0RdeRB/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942			_2Loc _cREF1
008			250602s9999 xx |||||s2 |||| ||und|d
999			_c44983 _d44983