000			02195nam a2200313Ia 4500
003			MX-MdCICY
005			20250625140641.0
040			_cCICY
090			_aB-10975
245	1	0	_aTargeted Liposomal Drug Delivery in Cancer
490	0		_vCurrent Pharmaceutical Design, 10(24), p.2981-2989, 2004
520	3		_aLiposomes, which are biodegradable and essentially non-toxic vehicles, can encapsulate both hydrophilic and hydrophobic materials, and are utilized as drug carriers in drug delivery systems. In addition, liposomes can be used to carry radioactive compounds as radiotracers can be linked to multiple locations in liposomes. One option is the hydrated compartment inside the liposome, another the lipid core into which especially hydrophobic conjugates can be attached, and the third option is the outer lipid leaflet where molecules can be bound by covalent linkage. Delivery of agents to the reticuloendothelial system (RES)is easily achieved, since most conventional liposomes are trapped by the RES. For the purpose of delivery of agents to target organs other than RES, long-circulating liposomes have been developed by modifying the liposomal surface. Understanding of the in vivo dynamics of liposome-carried agents is required for the evaluation of the bioavailability of drugs encapsulated in liposomes. In this review, we focus on the in vivo trafficking of liposomes visualized by positron emission tomography (PET)and discuss the characteristics of liposomes that affect the targeting of drugs in vivo.
650	1	4	_aLIPOSOMES
650	1	4	_aCANCER CHEMOTHERAPY
650	1	4	_aRADIONUCLIDE IMAGING
650	1	4	_aPHARMACOKINETICS
650	1	4	_aPHARMACODYNAMICS
650	1	4	_aPOSITRON EMISSION TOMOGRAPHY
650	1	4	_aCYTOTOXIC COMPOUNDS
650	1	4	_aTUMOR TARGETING
650	1	4	_aPHAGE DISPLAY PEPTIDES
650	1	4	_aMONOCLONAL ANTIBODIES
700	1	2	_aMedina, O.P.
700	1	2	_aZhu, Y.
700	1	2	_aKairemo, K.
856	4	0	_uhttps://drive.google.com/file/d/1zjH2N7aW1db2GU0v23SMZVJwUU2KMRT4/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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