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| 003 | MX-MdCICY | ||
| 005 | 20250625140649.0 | ||
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| 090 | _aB-11373 | ||
| 245 | 1 | 0 | _aAnti-Cancer Potential of Sesquiterpene Lactones: Bioactivity and Molecular Mechanisms |
| 490 | 0 | _vCurr. Med. Chem. - Anti-Cancer Agents, 5(3), p.239-249, 2005 | |
| 520 | 3 | _aSesquiterpene lactones (SLs)are the active constituents of a variety of medicinal plants used in traditional medicine for the treatment of inflammatory diseases. In recent years, the anti-cancer property of various SLs has attracted a great deal of interest and extensive research work has been carried out to characterize the anti-cancer activity, the molecular mechanisms, and the potential chemopreventive and chemotherapeutic application of SLs. In this review, we attempt to summarize the current knowledge of the anti-cancer properties of SLs by focusing on the following important issues. First, we discuss the structure-activity relationship of SLs. All SLs contain a common functional structure, an a- methylene-g-lactone group, and this important chemical characteristic means that the thiol-reactivity of SLs is an underlying mechanism responsible for their bioactivities. Second, we assess the experimental evidence for the anti-cancer function of SLs obtained from both in vitro cell culture and in vivo animal models. Various SLs have been demonstrated to execute their anti-cancer capability via inhibition of inflammatory responses, prevention of metastasis and induction of apoptosis. Thirdly, we outline the molecular mechanisms involved in the anti-cancer activity of SLs, in particular, the SLthiols reaction, the effect of SLs on cell signaling pathways such as nuclear transcription factor-kappaB (NF-kB)and mitogen-activated protein kinases (MAPK). Finally, we recapitulate some important SLs with regards to their anti-cancer activities and their potential in anti-cancer drug development. Taken together, many SLs are emerging as promising anticancer agents with potential applications in both cancer chemotherapy and chemoprevention. | |
| 650 | 1 | 4 | _aSESQUITERPENE LACTONES |
| 650 | 1 | 4 | _aANTI-CANCER |
| 650 | 1 | 4 | _aAPOPTOSIS |
| 650 | 1 | 4 | _aTHIOLS |
| 650 | 1 | 4 | _aANTI-INFLAMMATORY |
| 650 | 1 | 4 | _aNF-KB |
| 700 | 1 | 2 | _aZhang, S. |
| 700 | 1 | 2 | _aWon, Y.K. |
| 700 | 1 | 2 | _aOng, C.N. |
| 700 | 1 | 2 | _aShen, H.M. |
| 856 | 4 | 0 |
_uhttps://drive.google.com/file/d/1xUxje0H6tc4hAYMbuGQUg66WfLCrN2Vr/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
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