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003			MX-MdCICY
005			20250625140655.0
040			_cCICY
090			_aB-11669
245	1	0	_aInvestigation of antimicrobial and protease-inhibitory activity from cultured cyanobacteria
490	0		_vPharmaceutical Biology, 47(1), p.53-60, 2009
520	3		_aA culture collection of cyanobacteria has been established at the University of Illinois at Chicago. This collection includes marine, terrestrial, and freshwater strains and contains representatives of the five orders of cyanobacteria: Chroococcales, Pleurocapsales, Oscillatoriales, Nostocales, and Stigonematales. In this study, extracts from a subset of 61 strains, 16 marine and 45 freshwater/terrestrial, were evaluated against three current protease targets, i.e. 20S proteasome and two SARS viral proteases, two important bacterial targets, i.e. Mycobacterium tuberculosis and Bacillus anthracis, and in the Artemia salina toxicity assay. In total, extracts of 12 strains possessed significant levels of activity in one or more targets. The overwhelming majority of active extracts (11 of 12)were from either freshwater or terrestrial forms of cyanobacteria, with the greater part of these (9 of 12)being heterocyst-forming strains. These results further support the use of cultured cyanobacteria as a source of iologically active natural products.
650	1	4	_aANTHRAX
650	1	4	_aANTIMICROBIAL
650	1	4	_aBRINE SHRIMP
650	1	4	_aCYANOBACTERIA
650	1	4	_aPROTEASE INHIBITION
650	1	4	_aPROTEASOME
650	1	4	_aSARS
650	1	4	_aTUBERCULOSIS
700	1	2	_aChlipala, G.
700	1	2	_aMo, S.
700	1	2	_aCarcache De Blanco, E.J.
700	1	2	_aIto, A.
700	1	2	_aBazarek, S.
700	1	2	_aOrjala, J.
856	4	0	_uhttps://drive.google.com/file/d/1WY9PYW8kzXKJXf_npc2pgWecBVLFQKwA/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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