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090			_aB-11754
245	1	0	_aMedicinal Plants with Inhibitory Properties Against Snake Venoms
490	0		_vCurrent Medicinal Chemistry, 12(22), p.2625-2641, 2005
520	3		_aEnvenomations due to snake bites are commonly treated by parenteral administration of horse or sheep-derived polyclonal antivenoms aimed at the neutralization of toxins. However, despite the widespread success of this therapy, it is still important to search for different venom inhibitors, either synthetic or natural, that could complement or substitute for the action of antivenoms. Several plants have been utilized in folk medicine as antiophidian. However, only a few species have been scientifically investigated and still less had their active components isolated and characterized both structurally and functionally. This article presents a review of plants showing neutralizing properties against snake venoms which were assayed in research laboratories, correlating them with ethnopharmacological studies, as (i)the part of the plant used as antidote, (ii)its respective genus and family and (iii)inhibition of the main pharmacological, toxic and enzymatic activities of snake venoms and isolated toxins. Protective activity of many of these plants against the lethal action of snake venoms has been confirmed by biological assays. Compounds in all of them belong to chemical classes capable of interacting with macromolecular targets (enzymes or receptors). Popular culture can often help to guide scientific studies. In addition, biotechnological application of these inhibitors, as helpful alternative or supplemental treatments to serum therapy, and also as important models for synthesis of new drugs of medical interest, needs to be better oriented and scientifically explored.
650	1	4	_aMEDICINAL PLANTS
650	1	4	_aANTIOPHIDIAN PLANTS
650	1	4	_aANTI-SNAKE VENOM
650	1	4	_aTOXIN INHIBITORS
650	1	4	_aETHNOPHARMACOLOGICAL STUDIES
650	1	4	_aSTRUCTURAL APPROACHES
700	1	2	_aSoares, A.M.
700	1	2	_aTicli, F.K.
700	1	2	_aMarcussi, S.
700	1	2	_aLourenço, M.V.
700	1	2	_aJanuário, A.H.
700	1	2	_aSampaio, S.V.
700	1	2	_aGiglio, J.R.
700	1	2	_aGiglio, J.R.
700	1	2	_aPereira, P.S.
856	4	0	_uhttps://drive.google.com/file/d/159E0CEe3mqgwysiJiN2vVoHGh1BnPhNx/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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