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090			_aB-11952
245	1	0	_aGymnochromes E and F, Cytotoxic Phenanthroperylenequinones from a Deep-Water Crinoid, Holopus rangii
490	0		_vJ. Nat. Prod., 73(4), p.712-715, 2010
520	3		_aBioactivity-guided fractionation of metabolites from the crinoid Holopus rangii led to the discovery of two new phenanthroperylenequinone derivatives, gymnochromes E (1)and F (2). Gymnochrome E showed cytotoxic activity toward the NCI/ADR-Res with an IC50 of 3.5 ìM. It also inhibited histone deacetylase-1 with an IC50 of 3.3 ìM. Gymnochrome F was a moderate inhibitor of myeloid cell leukemia sequence 1 (MCL-1)binding to Bak. Two anthraquinone metabolites, emodic acid (4)and its new bromo derivative (5), were also isolated from the crinoid and show remarkable similarity to the phenanthroperylenequinone core, suggesting that these metabolites share the same polyketide biosynthetic pathway.
700	1	2	_aKemami Wangun, H.V.
700	1	2	_aWood, A.
700	1	2	_aFiorilla, C.
700	1	2	_aReed, J.K.
700	1	2	_aMccarthy, P.J.
700	1	2	_aWright, A.E.
856	4	0	_uhttps://drive.google.com/file/d/1I0lIamAPw6Y3GliBtV-RQRWqhM9r9lG0/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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