000			01847nam a2200241Ia 4500
003			MX-MdCICY
005			20250625140700.0
040			_cCICY
090			_aB-11953
245	1	0	_aNew Antiinfective and Human 5-HT2 Receptor Binding Natural and Semisynthetic Compounds from the Jamaican Sponge Smenospongia aurea
490	0		_vJ. Nat. Prod., 65(4), p.476-480, 2002
520	3		_aIn addition to the sesquiterpene-phenol aureols (1), 6¢-chloroaureol (2), and aureol acetate (3), eight indole alkaloids including the new N-3¢-ethylaplysinopsin (9)have been isolated from the Jamaican sponge Smenospongia aurea. Makaluvamine O (10), a new member of the pyrroloiminoquinone class, was also isolated. The structures were characterized by spectroscopic methods, and two new derivatives of aureol were prepared to optimize the biological activity. Aureol N,N-dimethyl thiocarbamate (1a)and 6-bromoaplysinopsin (7)exhibit significant antimalarial and antimycobacterial activity in vitro. Compound 6 showed activity against the Plasmodium enzyme plasmepsin II. The 6-bromo-2¢-de-N-methylaplysinopsin (6), 6-bromoaplysinopsin (7), and N-3¢-ethylaplysinopsin (9)displaced high-affinity [3H]antagonist ligands from cloned human serotonin 5-HT2 receptor subtypes, whereas the other compounds tested did not. Remarkably, the 6-bromo-2¢-de-N-methylaplysinopsin (6)showed a >40-fold selectivity for the 5-HT2C subtype over the 5-HT2A subtype.
700	1	2	_aHu, J.
700	1	2	_aSchetz, J.A.
700	1	2	_aKelly, M.
700	1	2	_aPeng, J.
700	1	2	_aAng, K.
700	1	2	_aFlotow, H.
700	1	2	_aLeong, C.
856	4	0	_uhttps://drive.google.com/file/d/1x_VDuMR1kvoXtQtDmvxmBQ6S6vlS4N3I/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942			_2Loc _cREF1
008			250602s9999 xx |||||s2 |||| ||und|d
999			_c46166 _d46166