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245 1 0 _aHIV-1 Ribonuclease H Inhibitory Phenolic Glycosides from Eugenia hyemalis
490 0 _vJ. Nat. Prod., 71(9), p.1634-1636, 2008
520 3 _aThree new galloyl arbutins, hyemalosides A-C (1-3), along with nine known compounds were isolated from the evergreen tree Eugenia hyemalis. The structures of compounds 1-3 were determined by analysis of NMR and MS data. Compounds 1-3 inhibited HIV-1 RNase H in Vitro with IC50 values of 1.46, >18, and 1.19 ìM, respectively. However, in a XTT-based cell viability assay using the human T-cell line CEM-SS infected with HIV-1RT, none of the compounds inhibited the cytopathic effect of HIV-1 infection at the highest dose tested (20 ìg/mL).
700 1 2 _aBokesch, H.R.
700 1 2 _aWamiru, A.
700 1 2 _aLe Grice, S.
700 1 2 _aBeutler, J.A.
700 1 2 _aMckee, T.C.
700 1 2 _aMcmahon, J.B.
856 4 0 _uhttps://drive.google.com/file/d/1OlrTbWnZZaZPVE9V3X6zBg3ocNbGWwzI/view?usp=drivesdk
_zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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