000			01852nam a2200253Ia 4500
003			MX-MdCICY
005			20250625140700.0
040			_cCICY
090			_aB-11955
245	1	0	_aNMR Strategy for Unraveling Structures of Bioactive Sponge-Derived Oxy-polyhalogenated Diphenyl Ethers
490	0		_vJ. Nat. Prod., 72(3), p.443-449, 2009
520	3		_aThe overexpression of the Mcl-1 protein in cancerous cells results in the sequestering of Bak, a key component in the regulation of normal cell apoptosis. Our investigation of the ability of marine-derived small-molecule natural products to inhibit this protein-protein interaction led to the isolation of several bioactive oxy-polyhalogenated diphenyl ethers. A semipure extract, previously obtained from Dysidea (Lamellodysidea)herbacea and preserved in our repository, along with an untouched Dysidea granulosa marine sponge afforded 13 distinct oxy-polyhalogenated diphenyl ethers. Among these isolates were four new compounds, 5, 6, 10, and 12. The structure elucidation of these molecules was complicated by the plethora of structural variants that exist in the literature. During dereplication, we established a systematic method for analyzing this class of compounds. The strategy is governed by trends in the 1H and 13C NMR shifts of the aromatic rings, and the success of the strategy was checked by X-ray crystal structure analysis.
700	1	2	_aCalcul, L.
700	1	2	_aChow, R.
700	1	2	_aOliver, A.G.
700	1	2	_aTenney, K.
700	1	2	_aWhite, K.N.
700	1	2	_aWood, A.W.
700	1	2	_aFiorilla, C.
700	1	2	_aFiorilla, C.
856	4	0	_uhttps://drive.google.com/file/d/1GroCp-dW8R1ZNept8rfvfBlRw_UG5wKy/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942			_2Loc _cREF1
008			250602s9999 xx |||||s2 |||| ||und|d
999			_c46168 _d46168