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090			_aB-21122
245	1	0	_aHypoglycemic effects of sesquiterpene lactones from Byrsonima crassifolia
490	0		_vFood Science and Biotechnology, 25, p.1135-1145, 2016
520	3		_aThe novel dimeric guaianolides sesquiterpene lactone Byrsoninas A and B from seed hexane extract of Byrsonima crassifolia were identified. Streptozotocin-induced mildly diabetic and severely diabetic mice were treated with these oral administrations at a dosage of 20 mg/kg of body weight per day for 30 days. Also the protective effect in vitro in RIN-5F cells against oxidative stress was investigated and TNF-? and IL-6 levels were measured. Both Byrsonina types reduced blood glucose, cholesterol, triglyceride, lipoprotein, and transaminase levels and increased HDL-cholesterol, antioxidant enzymes, and TBARS-reactive substance levels. Byrsoninas A and B both improved this glucose metabolism by reducing insulin resistance and by stimulating insulin production due to protection effect for pancreatic ?-cells against oxidative stress, lipid abnormalities were reduced and, chronic inflammation responses were alleviated producing a hepatoprotective role.
650	1	4	_aGUAIANOLIDES
650	1	4	_aANTIDIABETIC
650	1	4	_aHYPERLIPIDEMIA
650	1	4	_aBYRSONIMA CRASSIFOLIA
700	1	2	_aGutiérrez, R. M. P.
700	1	2	_aRamirez, A. M.
856	4	0	_uhttps://drive.google.com/open?id=1hxvRSm9ZpMYC7CO_cgkFDXjWu-EQ3dZL&usp=drive_copy _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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