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090			_aB-12242
245	1	0	_aAutocatalytic differentiation of epigenetic modifications within the Arabidopsis genome
490	0		_vThe EMBO Journal, 29, p.3496-3506, 2010
520	3		_aIn diverse eukaryotes, constitutively silent sequences, such as transposons and repeats, are marked by methylation at histone H3 lysine 9 (H3K9me). Although selective H3K9me is critical for maintaining genome integrity, mechanisms to exclude H3K9me from active genes remain largely unexplored. Here, we show in Arabidopsis that the exclusion depends on a histone demethylase gene, IBM1 (increase in BONSAI methylation). Loss-of-function ibm1 mutation results in ectopic H3K9me and non-CG methylation in thousands of genes. The ibm1-induced genic H3K9me depends on both histone methylase KYP/SUVH4 and DNA methylase CMT3, suggesting interdependence of two epigenetic marks-H3K9me and non-CG methylation. notably, IBM1 enhances loss of H3K9me in transcriptionally de-repressed sequences. Furthermore, disruption of transcription in genes induces ectopic non-CG methylation, which mimics the loss of IBM1 function. We propose that active chromatin is stabilized by an autocatalytic loop of transcription and H3K9 demethylation. This process counteracts a similarly autocatalytic accumulation of silent epigenetic marks, H3K9me and non-CG methylation.
650	1	4	_aCHROMATIN
650	1	4	_aDNA METHYLATION
650	1	4	_aHISTONE DEMETHYLASE
650	1	4	_aIBM1
650	1	4	_aTRANSPOSON
700	1	2	_aInagaki, S.
700	1	2	_aMiura-Kamio, A.
700	1	2	_aNakamura, Y.
700	1	2	_aLu, F.
700	1	2	_aCui, X.
700	1	2	_aCao, X.
700	1	2	_aKimura, H.
700	1	2	_aKimura, H.
700	1	2	_aKakutani, T.
856	4	0	_uhttps://drive.google.com/file/d/1zIs9SfQAtE4UpkuX9D_pcSskcGX3AUYI/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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