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245	1	0	_aThe impact of next-generation sequencing technology on genetics
490	0		_vTrends in Genetics, 24(3), p.133-141, 2008
520	3		_aIf one accepts that the fundamental pursuit of genetics is to determine the genotypes that explain phenotypes, the meteoric increase of DNA sequence information applied toward that pursuit has nowhere to go but up. The recent introduction of instruments capable of producing millions of DNA sequence reads in a single run is rapidly changing the landscape of genetics, providing the ability to answer questions with heretofore unimaginable speed. These technologies will provide an inexpensive, genome-wide sequence readout as an endpoint to applications ranging from chromatin immunoprecipitation, mutation mapping and polymorphism discovery to noncoding RNA discovery. Here I survey next-generation sequencing technologies and consider how they can provide a more complete picture of how the genome shapes the organism.
700	1	2	_aMardis, E.R.
856	4	0	_uhttps://drive.google.com/file/d/1AiPLqfM1P7kNZzKM0e54L4WAnqQW7qEi/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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