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090			_aB-12615
245	1	0	_aStructure-activity relationship (SAR)of parthenin analogues with pro-apoptotic activity: Development of novel anti-cancer leads
490	0		_vBioorganic & Medicinal Chemistry Letters, 19(15), p.4394-4398, 2009
520	3		_aAnalogues of parthenin were synthesized by substitutions at different reaction centres to establish a structure-activity relationship (SAR). Some of the molecules have displayed significant cytotoxicity in human cervical carcinoma (HeLa)and human myeloid leukemia (HL-60)cells. A few of the compounds also induced apoptosis in HL-60 cells measured in terms of sub-Go/G1 DNA fraction. Also one of the lead molecules has been shown to be the inhibitor of both telomerase and topoisomerase-II.
650	1	4	_aCYTOTOXICITY
650	1	4	_aAPOPTOSIS
650	1	4	_aTOPOISOMERASE-II
650	1	4	_aTELOMERASE
650	1	4	_aSAR
650	1	4	_aPARTHENIN
700	1	2	_aShah, B.A.
700	1	2	_aKaur, R.
700	1	2	_aGupta, P.
700	1	2	_aKumar, A.
700	1	2	_aSethi, V.K.
700	1	2	_aAndotra, S.S.
700	1	2	_aSingh, J.
700	1	2	_aSingh, J.
700	1	2	_aTaneja, S.C.
856	4	0	_uhttps://drive.google.com/file/d/1npSfPkTsDm20z3wr4KuqSBTBH-xCQRuB/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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