000			01396nam a2200241Ia 4500
003			MX-MdCICY
005			20250625153907.0
040			_cCICY
090			_aB-12721
245	1	0	_aSelective inhibition of cytosine-DNA methylases by polyamines
490	0		_vFEBS Letters, 357(2), p.192-196, 1995
520	3		_aWe have advanced the hypothesis that polyamines affect DNA methylation and thus promote the expression of developmentally controlled genes. We demonstrate that the activity of cytosine-DNA methyltransferases HpaII, HhaI, HaeIII and SssI is inhibited by physiological concentrations of polyamines. On the other hand, activity of the adenine-DNA methyltransferase EcoRI, and restriction enzymes HpaII, HhaI, HaeIII and EcoRI, is insensitive to polyamine concentrations up to 40 mM. Our results indicate that the effect of polyamines on cytosine- DNA methyltranferases is rather selective and suggest a possible mode of action in vivo.
650	1	4	_aPUTRESCINE
650	1	4	_aSPERMIDINE
650	1	4	_aDNA-METHYLATION
650	1	4	_aRESTRICTION ENZYME
700	1	2	_aRuiz-Herrera, J.
700	1	2	_aRuiz-Medrano, R.
700	1	2	_aDominguez, A.
856	4	0	_uhttps://drive.google.com/file/d/1Nw1MdMkeeIWcT168g2nIYrsWoEVuCZ9K/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942			_2Loc _cREF1
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999			_c46928 _d46928