000			02496nam a2200325Ia 4500
003			MX-MdCICY
005			20250625153914.0
040			_cCICY
090			_aB-13004
245	1	0	_aChemical Genetics Reveals Negative Regulation of Abscisic Acid Signaling by a Plant Immune Response Pathway
490	0		_vCurrent Biology, 21(7), p.990-997, 2011
520	3		_aCoordinated regulation of protection mechanisms against environmental abiotic stress and pathogen attack is essential for plant adaptationandsurvival. Initial abioticstresscaninterfere with disease-resistancesignaling[1-6].Conversely, initial plant immune signaling may interrupt subsequent abscisic acid (ABA)signal transduction [7, 8]. However, the processes involved in this crosstalk between these signaling networks have not been determined. By screening a 9600-compound chemical library,weidentifiedasmallmolecule [5-(3,4-dichlorophenyl)furan-2-yl]-piperidine-1-ylmethanethione (DFPM)that rapidly downregulates ABA-dependent gene expression and also inhibits ABA-induced stomatal closure. Transcriptome analyses show that DFPM also stimulates expression of plant defense-related genes.Major early regulators of pathogen- resistanceresponses, includingEDS1,PAD4,RAR1,and SGT1b, are required for DFPM-and notably also for Pseudomonas- interference with ABA signal ansduction, whereas salicylic acid, EDS16, and NPR1 are not necessary. Although DFPM does not interfere with early ABA perception by PYR/RCAR receptors or ABA activation of SnRK2 kinases, it disrupts cytosolic Ca2+ signaling and downstream anion channel activation in a PAD4-dependentmanner. Our findings provide evidence that activation of EDS1/PAD4-dependent plant immune responses rapidly disrupts ABA signal transduction and that this occurs at the level of Ca2+ signaling, illuminating how the initial biotic stress pathway interferes with ABA signaling.
700	1	2	_aKim, T.
700	1	2	_aHauser, F.
700	1	2	_aHa, T.
700	1	2	_aXue, S.
700	1	2	_aBohmer, M.
700	1	2	_aNishimura, N.
700	1	2	_aMunemasa, S.
700	1	2	_aMunemasa, S.
700	1	2	_aPeine, N.
700	1	2	_aLee, B.
700	1	2	_aLee, S.
700	1	2	_aRobert, N.
700	1	2	_aParker, J.E.
700	1	2	_aSchroede, J.I.
856	4	0	_uhttps://drive.google.com/file/d/1xw2ugkejx7CjSF-ENGpROgav93i2N6Pn/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942			_2Loc _cREF1
008			250602s9999 xx |||||s2 |||| ||und|d
999			_c47206 _d47206