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090			_aB-13072
245	1	0	_aAnalysis of Intact Protein Isoforms by Mass Spectrometry
490	0		_vThe Journal of Biological Chemistry, 286, p.25451-25458, 2011
520	3		_aThe diverse proteome of an organism arises from such events as single nucleotide substitutions at the DNA level, different RNA processing, and dynamic enzymatic post-translational modifications. This minireview focuses on the measurement of intact proteins to describe the diversity found in proteomes. The field of biological mass spectrometry has steadily advanced, enabling improvements in the characterization of single proteins to proteins derived from cells or tissues. In this minireview, we discuss the basic technology for "top-down" intact protein analysis. Furthermore, examples of studies involved with the qualitative and quantitative analysis of full-length polypeptides are provided.
700	1	2	_aTipton, J.D.
700	1	2	_aTran, J.C.
700	1	2	_aCatherman, A.D.
700	1	2	_aAhlf, D.R.
700	1	2	_aDurbin, K.R.
700	1	2	_aKelleher, N.L.
856	4	0	_uhttps://drive.google.com/file/d/1blZS5xnD3qIndW3NfmKWJj2JbF8FkQk-/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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