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090			_aB-13100
245	1	0	_aResveratrol and cardiovascular health
490	0		_vMolecular Aspects of Medicine, 31, p.503-512, 2010
520	3		_aResveratrol (3,40,5-trihydroxystilbene)is a member of natural, plant-derived chemicals known as polyphenols and is attracting increased attention due to its diverse health benefits especially in case of cardiovascular disease, cancer, diabetes and neurological problems. Despite impressive gains in diagnosis and treatment, cardiovascular disease (CVD)remains a serious clinical problem and threat to public health. Resveratrol possesses potent antioxidant properties and has been shown to decrease low-density lipoprotein-cholesterol oxidation and platelet aggregation. This compound also possesses a range of additional cardioprotective and vasoprotective properties including antiatherosclerotic and vasorelaxation action. Resveratrol also has the capacity to interact with multiple molecular targets, which involve diverse intracellular pathways. Most well-known is the ability of resveratrol to activate sirtuins, a class of NAD+-dependent deacetylase that affect multiple transcription factors and other protein targets. Recently, resveratrol was found to induce autophagy and regenerate myocardial ischemic tissue treated with stem cells. Overall observation indicates that resveratrol has a high therapeutic potentials for the treatment of cardiovascular diseases.
650	1	4	_aRESVERATROL
650	1	4	_aCARDIOVASCULAR DISEASE
650	1	4	_aATHEROSCLEROSIS
650	1	4	_aANGIOGENESIS
650	1	4	_aMYOCARDIAL REGENERATION
650	1	4	_aAUTOPHAGY
650	1	4	_aISCHEMIC REPERFUSION INJURY
650	1	4	_aHYPERTENSION
650	1	4	_aSTEM CELLS
650	1	4	_aSIRT
650	1	4	_aFOXO
700	1	2	_aDas, M.
700	1	2	_aDas, D.K.
856	4	0	_uhttps://drive.google.com/file/d/1BWuABA1-W81njCStzO9dWM3AwoZCF_kV/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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