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090			_aB-13118
245	1	0	_aCollagen nerve conduits releasing the neurotrophic factors GDNF and NGF
490	0		_vJournal of Controlled Release, 143(2), p.168-174, 2010
520	3		_aArtificial nerve conduits (NC)can clinically be instrumental for facilitating the surgery of damaged peripheral nerves. To improve axonal regeneration of injured peripheral nerves, we have developed collagen nerve conduits (NC)releasing glial cell line-derived neurotrophic factor (GDNF)alone or in combination with nerve growth factor (NGF), which exert synergistic action on axonal growth. Degradation of the NC and their mechanical and drug release properties were controlled by two means: (i)cross-linking the collagen tubes by physical means, through a dehydro-thermal treatment (DHT), before loading with the neurotrophic factors (NTFs)GDNF or GDNF/NGF; and (ii)coating the drug-loaded collagen tubes with layers of poly (lactide-co-glycolide)(PLGA). Non-cross-linked collagen NC (C-NC)released high amounts of NTFs during the initial 2.3 days of incubation, whereas the DHT-treated collagen NC (Cdht-NC)did not show a prominent burst effect. The release kinetics was similar for DNF alone and GDNF co-delivered with NGF. Within 30 days, the C-NC released 78
650	1	4	_aGROWTH FACTORS
650	1	4	_aCONTROLLED CO-DELIVERY
650	1	4	_aNERVE CONDUITS
650	1	4	_aCOLLAGEN
650	1	4	_aMECHANICAL STABILITY
650	1	4	_aDORSAL ROOT GANGLIA
700	1	2	_aMadduri, S.
700	1	2	_aFeldman, K.
700	1	2	_aTervoort, T.
700	1	2	_aPapaloïzos, M.
700	1	2	_aGander, B.
856	4	0	_uhttps://drive.google.com/file/d/1x4J2m4wbpZFvWrMXLtjrR9taMjyVwCNK/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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