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245	1	0	_aScale-up of a pharmaceutical granulation in fixed bowl mixer-granulators
490	0		_vInternational Journal of Pharmaceutics, 133(1-2), p.127-131, 1996
520	3		_aScale-up in fixed bowl mixer-granulators has been studied by applying the classical dimensionless numbers of Power, Reynolds and Froude to end-point prediction in a range of geometrically similar machines. The simple relationship of Power number/Reynolds number, as suggested by previous workers, has been found to be nappropriate for large-scale production machines where corrections have to be made for gross vortexing and powder bed height variation by the incorporation of the Froude number and a scaling factor. When corrections are made, data from 25-, 100- and 600-1 machines all fall on the same curve allowing predictions of optimum granulation end-point conditions to be made for production-scale equipment from measurements on laboratory-scale equipment and vice-versa.
650	1	4	_aGRANULATION
650	1	4	_aMIXER GRANULATORS
650	1	4	_aSCALE-UP
700	1	2	_aLandin, M.
700	1	2	_aYork, P.
700	1	2	_aCliff, M.J.
700	1	2	_aRowe, R.C.
700	1	2	_aWigmore, A.J.
856	4	0	_uhttps://drive.google.com/file/d/1vvguDzaJTI19g8n1JPJrhEwPVrF3zQIf/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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