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245	1	0	_aModeling of cortical bone adaptation in a rat ulna: Effect of frequency
490	0		_vBone, 50, p.792-797, 2012
520	3		_aWe employ a recently developed model for the adaptation of cortical bone in response to mechanical loading to study the effect of loading frequency on the computed response, and we compare our results to previous experimental measurements on rat ulnae. We represent the cortical bone as a poroelastic material with orthotropic permeability. Bone adaptation in the model is related to a mechanical stimulus derived from the dissipation energy of the poroelastic flow induced by deformation. We account for a non-locality in the mechanotransduction of osteocytes present in the lacunae by using a "zone of influence." Calculations are done using the finite element method applied to a rat ulna whose geometry is obtained from microcomputed tomography images. We show that the change in the second moment of inertia of the crosssection increases non-linearly and saturates at higher frequency range. The numerical results are then compared quantitatively to experimental data from the literature. Finally, we examine the role of local narrowing of intramedullary canal in our specific ulna in the development of local irregularities in growth.
650	1	4	_aPOROELASTICITY
650	1	4	_aDISSIPATION ENERGY
650	1	4	_aINTERSTITIAL FLUID FLOW
650	1	4	_aCORTICAL BONE ADAPTATION
650	1	4	_aFINITE ELEMENT MODELING
650	1	4	_aEVOLUTION LAW
700	1	2	_aChennimalai Kumar, N.
700	1	2	_aDantzig, J.A.
700	1	2	_aJasiuk, I.M.
856	4	0	_uhttps://drive.google.com/file/d/1gQvn9_mhGHVxC-w_ux20wzZOGtuVYRDi/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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