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090			_aB-13701
245	1	0	_aTag-based approaches for transcriptome research and genome annotation
490	0		_vNature Methods, 2, p.495-502, 2005
520	3		_aWith the increasing number of whole genome sequences available, genomic research has shifted toward the annotation of functional elements and transcribed regions. Thus, the related field of transcriptome research requires accurate methods for the profiling of genes that are not biased by known sequence information, and that also allow for the identification of promoter regions. Starting with serial analysis of gene expression (SAGE), methods making use of short sequencing tags have greatly contributed to transcriptome studies. Here we review recent developments in the use of short sequencing tags in expression profiling, gene discovery and genome nnotation. These tags are obtained from the 5_O end of mRNAs, both terminal ends of mRNAs, or genomic regions. The 5_O end.specific tags, with their ability to identify transcripts along with their transcriptional start sites, will be of particular interest for gene network studies and may become one of the most important approaches in systems biology.
700	1	2	_aHarbers, M.
700	1	2	_aCarninci, P.
856	4	0	_uhttps://drive.google.com/file/d/1Qfak7IswbeQsRSPqeofOcCL_C_tSvTjG/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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