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245	1	0	_aFeedback models for polarized auxin transport: an emerging trend
490	0		_vMolecular BioSystems, 7(8), p.2352-2359, 2011
520	3		_aThe phytohormone auxin is vital to plant growth and development. A unique property of auxin among all other plant hormones is its cell-to-cell polar transport that requires activity of polarly localized PIN-FORMED (PIN)auxin efflux transporters. Despite the substantial molecular insight into the cellular PIN polarization, the mechanistic understanding for developmentally and environmentally regulated PIN polarization is scarce. The long-standing belief that auxin modulates its own transport by means of a positive feedback mechanism has inspired both experimentalists and theoreticians for more than two decades. Recently, theoretical models for auxin-dependent patterning in plants include the feedback between auxin transport and the PIN protein localization. These computer models aid to assess the complexity of plant development by testing and predicting plausible scenarios for various developmental processes that occur in planta. Although the majority of these models rely on purely heuristic principles, the most recent mechanistic models tentatively integrate biologically testable components into known cellular processes that underlie the PIN polarity regulation. The existing and emerging computational approaches to describe PIN polarization are presented and discussed in the light of recent experimental data on the PIN polar targeting.
700	1	2	_aWabnik, K.
700	1	2	_aGovaerts, W.
700	1	2	_aFriml, J.
700	1	2	_aKleine-Vehn, J.
856	4	0	_uhttps://drive.google.com/file/d/1sWyEiG3wfe92NTg8MaO9PH8aEveTt7cM/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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