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090			_aB-14251
245	1	0	_aTriazole fungicides and the selection of resistance to medical triazoles in the opportunistic mould Aspergillus fumigatus
490	0		_vPest Management Science, 69(2), p.165-170, 2012
520	3		_aAzole resistance is an emerging problem in the opportunistic mould Aspergillus fumigatus. The triazoles are the most important agents for themanagementof Aspergillus diseases in humans. Selection for acquired resistancemay occur in the hospital setting through exposure to high doses of azoles during azole therapy, but evidence is accumulating that A. fumigatus may become resistant to medical triazoles through environmental exposure to fungicides. The recovery of A. fumigatus isolates resistant to the medical triazoles from azole-naive patients as well as from the environment strongly indicates an environmental route of resistance selection. Molecule alignment studies have identified five fungicides that share a very similar molecule structure with the medical triazoles, and thus may have selected for mechanisms that confer resistance to both groups of compounds. It is important to explore further the presumed fungicide-driven route of resistance selection in order to implement effective preventive measures as the prevalence of azole resistance in A. fumigatus continues to increase and causes major challenges in themanagement of azole-resistant Aspergillus diseases.
650	1	4	_aASPERGILLUS FUMIGATUS
650	1	4	_aTRIAZOLES
650	1	4	_aRESISTANCE
650	1	4	_aDEMETHYLASE INHIBITORS
650	1	4	_aASPERGILLOSIS
700	1	2	_aVerweij, P.E.
700	1	2	_aKema, G.H.J
700	1	2	_aZwaan, B.
700	1	2	_aMelchers, W.J.G.
856	4	0	_uhttps://drive.google.com/file/d/1Ovgg3rTAs0P60_af353lD-oaxHbQXamI/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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