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090			_aB-14336
245	1	0	_aThe blueprint of the type-3 injectisome
490	0		_vPhil. Trans. R. Soc., 367(1592), p.1140-1154, 2012
520	3		_aType-3 secretion systems are sophisticated syringe-like nanomachines present in many animal and plant Gram-negative pathogens. They are capable of translocating an arsenal of specific bacterial toxins (effector proteins)from the prokaryotic cytoplasm across the three biological membranes directly into the eukaryotic cytosol, some of which modulate host cell mechanisms for the benefit of the pathogen. They populate a particular biological niche, which is maintained by specific, pathogen-dependent effectors. In contrast, the needle complex, which is the central component of this specialized protein delivery machine, is structurally well-conserved. It is a large supramolecular cylindrical structure composed of multiple copies of a relatively small subset of proteins, is embedded in the bacterial membranes and protrudes from the pathogen's surface with a needle filament. A central channel traverses the entire needle complex, and serves as a hollow conduit for proteins destined to travel this secretion pathway. In the past few years, there has been a tremendous increase in an understanding on both the structural and the mechanistic level. This review will thus focus on new insights of this remarkable molecular machine.
650	1	4	_aMICROBIAL PATHOGENESIS
650	1	4	_aTYPE-3 SECRETION
650	1	4	_aSTRUCTURE
650	1	4	_aDISSECTION
650	1	4	_aFUNCTION
650	1	4	_aSALMONELLA
700	1	2	_aKosarewicz, A.
700	1	2	_aKönigsmaier, L.
700	1	2	_aMarlovits, T.C.
856	4	0	_uhttps://drive.google.com/file/d/1NnFWF-1i9qrN6SvtzjLNk0JSfKPfJSWf/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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