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090			_aB-14389
245	1	0	_aBiological principles for the effects of ethanol
490	0		_vEnzyme Microb. Technol., 11(3), p.130-153, 1989
520	3		_aBiological principles for the effects of ethanol are deduced from a study of some 60 different cell types ranging from bacteria, yeasts, and fungi to animal and plant cells. The direct effects of ethanol against metabolic pathways appears to be minimal, and the observed effects are more a reflection of ethanol metabolism rather than ethanol per se. Roles for NAD/NADH imbalances, acetaldehyde accumulation, and for the deactivation (i.e., switching off)of replicative processes emerge as central mechanisms. In the yeast-ethanol fermentation, it is suggested that the ability to avoid acetaldehyde accumulation is a prerequisite to so-called ethanol tolerance. Membrane-related effects due to ethanol are also involved. However, the spectrum of these effects may be such that different loci are involved at different ethanol concentrations. These effects are due to the polar, dielectric, and hydrogen-bond interactions of ethanol with membrane proteins and with the surface groups of the membrane. Competition for, and displacement of, bound cellular water will also occur. The so-called lipophilic effects of ethanol are shown to be minimal. Strategies and mechanisms for ethanol tolerance are discussed.
650	1	4	_aETHANOL; YEAST
650	1	4	_aFUNGI
650	1	4	_aPLANT CELL
650	1	4	_aBACTERIA
650	1	4	_aACETALDEHYDE
650	1	4	_aINHIBITION
650	1	4	_aTOXICITY
650	1	4	_aALCOHOL DEHYDROGENASE
650	1	4	_aREPLICATION
650	1	4	_aMEMBRANE
650	1	4	_aDEACTIVATION
700	1	2	_aJones, R.P.
856	4	0	_uhttps://drive.google.com/file/d/1sox7jrQ0tPvLjOcamU6MtilreGOaaPyr/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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